The high bridge, the courthouse clock, church steeples, docked boats, Victorian mansions on the bluff and the red brick warehouses - these are the images that make up Muscatine - The Pearl of the Mississippi. Tucked between two river bluffs, Muscatine is a charming riverfront community rich in culture and history. From its century-old business district, complete with its very own trolley, to its outstanding sports facilities and recreational areas, Muscatine and the Holiday Inn will leave you with memories to last a lifetime. Whether your visit brings you to us for business or pleasure, the Holiday Inn is ready to serve you. Our hotel features 112 graciously designed guestrooms and suites, catering to the corporate, group and leisure traveler. Located at the Junction of Highway 61 and 38 in Muscatine, Iowa. From I-80, exit 271 than 12 miles South on US38. From I-280, exit on Highway 61 West to Muscatine for 20 miles.