Situated directly opposite Marylebone Tube Station, in Marylebone, one of London's most up-market districts, the Landmark London is within a short distance from the Oxford Circus, the Piccadilly Circus, and the theater district.

It is a classic example of Victorian Gothic Architecture, most apparent on the exterior, which features icons, red brickwork, and beautiful arch detailing. Inside the hotel, the centerpiece is the eight-story glass atrium, which can be viewed from all internal facing guestrooms. The style is classic British, with some Eastern influences hinting at the hotels Thai ownership.

The hotel features 252 rooms and 47 suites, each with an executive desk, a private bar, high-speed Internet access, and marble bathroom. Most bathrooms have a separate bathtub and walk-in shower.