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The Hampton Inn Orangeburg is located off of I-26 at exit 145A. Exit will lead to 601 South and hotel is 1/2 mile on right side. The hotel is within 1/2 mile of The Regional Medical Center and 4 miles of S. State University and Claflin College. Edisto Memorial Rose Gardens is within 5 miles. Local restaurants and businesses are easily accessible from the hotel usually within a 3-10 mile radius.